Biomedical engineering seniors participated in the Undergraduate Research Symposium on Thursday, April 25, in which they presented their honors theses and fielded questions based on their research. Below is a list of students, their theses, and advisors.
- Alaa Abdelgawad’s honors thesis was titled “Investigation of Acute Radiation-Induced Changes in Oxygenation in a Murine Beast Tumor Model.” She was advised by Narasimhan Rajaram.
- Andre Figueroa’s honors thesis was titled “Design of Microporous Membranes for the Development of Brain-on-Chip Devices.” He was advised by Kartik Balachandran.
- Baylor Bush’s Honors Thesis was titled “A Bioinstrumentation Active Learning Educational Module: The Design of a Working Temperature Sensor Using a NTC Thermistor,” advised by Michelle Kim.
- Emma Sullivan’s honor thesis was titled “Generation of a CCL2 Knockout Using CRISPR/Cas9 and Lipid Mediated Transfection in CT-26 Murine Colon Carcinoma Cells,” advised by Timothy Muldoon.
- Jackson Hedrick’s honors thesis was titled “Phenotypic Characterization of Differentiation of Human Mesenchymal Stem Cells to Smooth Muscle Cells,” advised by Raj Rao.
- Josh Fahy honors thesis was titled “Role of Angiotensin I and II on the Tissue Mechanics of the Aortic Heart Valve,” advised by Kartik Balachandran.
- Katelyn Heath’s honor thesis was titled “Modeling and Validation of Tissue Optical Properties in the Photon Transport Regime,” advised by Timothy Muldoon.
Pictured: Alaa Abdelgawad
- Katie Brandecker’s honor thesis was titled “Effect of Polymer Composition of Injectable Hydrogels on Cumulative Release of Methylene Blue,” advised by Ryan Tian.
- Kristyn Robling’s honor thesis was titled “Characterization of Ocone Mediated TEMPO-Oxidized Nano Cellulose Mixed-Matrix Membranes During Ultrafiltration and Hemodialysis,” advised by Jamie Hestekin.
- Lauren Buchele’s honor thesis was titled “How Infant Positioning Impacts Hip Motion and the Associated Implications for Babies with Hip Displasia,” advised by Erin Mannen.
- Marinna Tadros’s honor thesis was titled “Designing In-Vitro Mitral Valve Mounting and Testing System for Micro CT.” She was advised by Morten Jensen.
- Mason Belue’s honor thesis was titled “Vector Flor Imaging in Pediatric Cardiology—Extracting and Validating Data,” also advised by Morten Jensen.
- Olga Brazhkina’s honor thesis was titled “Development of a Model for Accelerated Fatigue Testing in Venous Valves,” advised by Morten Jensen.
- Tasha Repella’s honor thesis was titled “Comparing the Effects of Fibroblast Growth Factors on Growth Rate of Human Fibroblast Cell Lines,” advised by Raj Rao.
- Wenbo Xu’s honor thesis was titled “Investigating Virus Clearance via pH Inactivation During Biomanufacturing,” advised by Xianghong Qian.
Two students also presented their independent research projects:
- Shelby Bess’ project was titled “Diffuse reflectance spectroscopy quantifies functional tumor response in a murine subcutaneous model of colorectal cancer,” advised by Timothy Muldoon.
- Shelby Johns also discussed her project, titled “Development of a C57BI6J Mouse Model for Calcific Aortic Valve Disease Progression,” advised by Kartik Balachandran.
Afterwards, students participated in the Poster Reception for Honors Research & Independent Study, in which members of the department and college could further explore and ask questions.
Congrats to the 2019 biomedical engineering seniors on their thesis completion!
Hogeye Marathon Relay Team from Now Diagnostics (Anne Preut second from right)
Anne Preut is a graduate of University of Arkansas’ Biomedical Engineering Department. Below, she describes her experience as a Product Development Scientist at Now Diagnostics and seeking employment post-graduation.
In November 2018, I started at Now Diagnostics (Springdale, AR) working as a Product Development Scientist. After graduation in May and a celebratory road-trip through the Southwest, I began the job hunt. Specifically, I was looking for a position that would challenge me, provide mentorship and positively impact healthcare through low-cost solutions and increased access for people. Now Diagnostics seemed to fit the description when a fellow graduate student at the University of Arkansas described the company to me. I reached out to see if and what positions were available. Cold-calling can be intimidating, but I would like to take a moment to encourage students to email or call the companies that they are truly passionate about. It only takes a moment and what’s the worst that can happen? The persistence paid off as I landed a phone interview with Vicki Thompson, who is my current boss. She then invited me to meet her Product Development Team as well as meet with the rest of the management team and CEO. After the interview, I knew this was a company where I could develop professionally and build a career (and thankfully they hired me!). Skills such as image analysis and 3D printing that I gained through the Biomedical Engineering Graduate Program at the University of Arkansas have been instrumental to growing in this new position. Most importantly, I have continued to grow as an independent researcher and build on my previous experiences as a graduate research student.
BioDot RR120 Web Handling System
Image analysis was instrumental in my thesis work as well as one of the most challenging and rewarding classes I took during graduate school. Understanding the basic principles of image analysis has been helpful as I work to scale-up the production of our hCG test. The equipment that I use includes a vision system to ensure that coating each membrane occurs in the programmed location. Additionally, understanding these principles has enabled me to effectively communicate with the manufacturer of the equipment.
Another core component to my thesis work was 3D printing in order to develop a neurovascular model. Using this knowledge, I initiated a unique solution to an issue on our scale-up equipment. We run multiple sizes of membrane on the equipment, which requires readjusting the dispense reels that hold the membrane rolls. Through the NWA Fab Lab in Fayetteville, AR I 3D printed components that appropriately space each membrane to be perfectly centered, which ensures coating in the desired locations. Although a simple solution, this minimizes setup time and ensures proper alignment of the membrane for every use.
3D printing at the Fab Lab
Finished product on scale-up equipment
As an undergraduate, I worked in three labs, yet graduate school gave me the opportunity to work independently driving my own research ideas through the guidance of my advisors, initiated through classes and collaboration with fellow graduate students. This has been the most instrumental in preparing me for my current position. Every day requires new iterations to my research as I work to scale-up our hCG test and prepare for the tech transfer for our Strep test.
This is the challenging environment that I envisioned when I began my job hunt, but even more so I am thankful for the supportive, encouraging and friendly atmosphere that Now Diagnostics embodies. In February, a coworker initiated a fitness challenge for everyone to walk one-mile per day. This resulted in almost half of the company completing the challenge as well as three coworkers and myself completing the Hogeye Marathon Relay. I know that the Biomedical Engineering Graduate Program has been foundational to building my skill set and I look forward building these friendships as well as my career at Now Diagnostics.
We are excited to welcome Dr. Christopher Nelson to the University of Arkansas Department of Biomedical Engineering. Dr. Nelson will join the department as an assistant professor in June 2019.
Dr. Nelson completed his Bachelor’s Degree in Biological Engineering at the University of Arkansas, and his PhD from Vanderbilt University. Dr. Nelson is currently pursuing research at Duke University supported by The Hartwell Foundation Postdoctoral Fellowship and the prestigious NIH Pathway to Independence Award (K99/R00).
Dr. Nelson’s primary research interests are in developing new technologies for therapeutic genome engineering. Previously, he has developed biomaterial-based platforms for drug and gene delivery including a nanoparticle for systemic siRNA administration (ACS Nano 2013) and a multifunctional scaffold for local gene silencing for regenerative medicine (Advanced Materials 2014). More recently, he has applied a genome engineering approach to treat the genetic basis of Duchenne muscular dystrophy in vivo (Science 2016). Dr. Nelson now plans to apply gene and drug delivery to genome engineering to create precision molecular therapies, study regenerative medicine, and interrogate gene function and regulation.
Welcome, Dr. Nelson!
Congratulations to Dr. Kartik Balachandran and Dr. Timothy Muldoon, who were each recently promoted to Associate Professor of Biomedical Engineering with tenure. Both Dr. Muldoon and Dr. Balachandran have been with the UArk Biomedical Engineering Department since its inception, and both are celebrated mentors, teachers, and researchers within the Department.
L-R: Dr. Kyle Quinn, Lexi Betts, Hope Hesterly, Alexis Bryant, and Trey Jeffus
On Tuesday, October 10, four students from Camden Fairview High School visited Dr. Kyle Quinn’s lab at the U of A. The four students—Lexi Betts, Hope Hesterly, Alexis Bryant, and Trey Jeffus—are all current high school juniors, as well as participants in the Student Spaceflight Experiments Program [or SSEP], a program of the National Center for Earth and Space Science Education (NCESSE) in the U.S. and the Arthur C. Clarke Institute for Space Education.
Dr. Jeffrey Wolchok
Congratulations to Associate Professor Jeffrey Wolchok, who was recently awarded an Investigator Award from the Arkansas Biosciences Institute (ABI), an agricultural and medical research consortium dedicated to improving the health of Arkansans. The Investigator Awards are designed to help enable researchers like Dr. Wolchok to further “explore many different body and cellular processes in their search for answers to challenging basic science and health related questions.” Dr. Wolchok’s particular research interests include biomaterials, tissue engineering and regenerative medicine, bioreactors and the influence of mechanical force on cell behavior, as well as the design of medical devices. Dr. Wolchok has been with the Biomedical Engineering Department since its inception, and was recently awarded the 2017 Departmental award for Outstanding Achievement in Service.